Early combination disease modifying antirheumatic drug treatment for rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Cost-effectiveness of combination nonbiologic disease-modifying antirheumatic drug strategies in patients with early rheumatoid arthritis.
OBJECTIVE To compare the costs and benefits of alternative combination strategies of disease-modifying antirheumatic drugs (DMARD) and DMARD monotherapy in patients with early, active rheumatoid arthritis (RA). METHODS Data were drawn from randomized controlled trials that compared DMARD monotherapy or any DMARD combination strategy, with or without combined steroid therapy. Mixed treatment c...
متن کاملCombination disease-modifying antirheumatic drug therapy reduced work disability in early rheumatoid arthritis.
M e t h o d s Design: Randomized controlled trial (Finnish Rheumatoid Arthritis Combination Therapy trial). Allocation: {Concealed}†.* Blinding: Blinded {outcome assessors}†.* Follow-up period: 5 years. Setting: 18 hospitals in Finland. Patients: 162 patients 18 to 65 years of age (mean age 45.5 y, 62% women) with RA of recent onset (< 2 y) and presence of active disease who had never received ...
متن کاملBaricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease‐Modifying Antirheumatic Drug Treatment
OBJECTIVE We undertook this phase III study to evaluate baricitinib, an orally administered JAK-1/JAK-2 inhibitor, as monotherapy or combined with methotrexate (MTX) compared to MTX monotherapy in patients with active rheumatoid arthritis (RA) who had received no or minimal conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and who were naive to biologic DMARDs. METHODS A t...
متن کاملDisease-modifying antirheumatic drug therapy for psoriatic arthritis.
As erosive and deforming arthritis is present in 40% of patients with psoriatic arthritis (PsA), early and aggressive treatment with disease-modifying antirheumatic drugs (DMARDs) may be as effective in controlling the progression of the disease as it is for rheumatoid arthritis (RA). Methotrexate (MTX), sulfasalazine (SSZ), and cyclosporine (CsA) are the most widely used DMARDs in the treatmen...
متن کاملPharmacotherapeutic strategies for disease-modifying antirheumatic drug (DMARD) combinations to treat rheumatoid arthritis (RA).
OBJECTIVE To provide a rational model for the use of disease-modifying antirheumatic drug (DMARD) combinations in the treatment of rheumatoid arthritis. METHODS The DMARDs used today were examined for their mechanisms of action, kinetics, and toxicity, and collected into tabular formats for easier comparison. From these tables, matrices of potential positive or negative interfaces among combi...
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ژورنال
عنوان ژورنال: Medical Journal of Australia
سال: 2006
ISSN: 0025-729X,1326-5377
DOI: 10.5694/j.1326-5377.2006.tb00150.x